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Health researchSun 25 Oct 2026 · 6 of 10

SGLT2 Inhibitors Show Mortality and Kidney Benefits but Higher Cardiac Risks in Adults 80+ with CKD

Verified · 9/9 supported1 cited · 1 min read

Medical Xpress reports that the analysis used electronic health records of 10,076 adults aged 80 years or older with chronic kidney disease . Medical Xpress reports that initiating SGLT2 inhibitor therapy was linked to an 18% reduction in all‑cause mortality over a two‑year follow‑up . Medical Xpress reports that the same therapy was linked to a 22% reduction in major adverse kidney events over the same period . Medical Xpress reports that SGLT2 inhibitors showed no significant effect on major adverse cardiovascular events overall, but were associated with higher risks of specific cardiac events such as heart attacks and acute heart failure . Medical Xpress reports that SGLT2 inhibitors were also associated with a higher risk of acute kidney injury, and the findings will be presented at ASN Kidney Week 2026 on October 22–25 .

Why it matters. Medical Xpress reports that the presentation at ASN Kidney Week will inform clinicians about the potential mortality and kidney benefits and the elevated cardiac and acute kidney injury risks of SGLT2 inhibitors for patients aged 80 and older with CKD .

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