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Health researchSun 1 Nov 2026 · 5 of 10

Blocking TET2 May Reverse Radiation-Induced Immune Suppression in Cancer

Verified · 6/6 supported1 cited · 1 min read

Medical Xpress reports that researchers at the University of Chicago identified a mechanism to make immune cells reprogrammed by radiation therapy attack tumors rather than protect them . Medical Xpress reports that radiation activates the protein TET2 on bone‑marrow immune cells, removing chemical tags from RNA and locking them into an immune‑suppressing state . Medical Xpress reports that blocking TET2 causes these immune cells to fight cancer, enhancing the effectiveness of radiation and immunotherapy to shrink tumors and control metastasis . Medical Xpress reports that radiation therapy is administered to 50%–60% of cancer patients and kills tumor cells by damaging DNA . Medical Xpress reports that radiation can trigger the expansion of myeloid‑derived suppressor cells (MDSCs), which travel to tumors and block CD8⁺ T cells, the primary tumor‑killing immune cells .

Why it matters. Medical Xpress notes that targeting TET2 could improve the anti‑cancer impact of radiation and immunotherapy by shrinking tumors and controlling metastasis for patients receiving radiation .

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